Protein Details: Potassium channel subfamily K member 18

Protein ID

ICDB_Pro_1120

Protein Name

Potassium channel subfamily K member 18

Gene Name

Kcnk18; Tresk-2; Tresk2

Organism

Mus musculus (Mouse)

Length

394 amino acids

AlphaFoldDB

AF-Q6VV64-F1-model_v4.pdb

Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin; whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics; such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool; an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.

Sequence

MEAEEPPEARRCCPEALGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDDLCNILKCNLTVVEGSRKNLCEHLQHLKPQWLKAPQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKWRSLPLCRKQPDSKPVEEAIPQIVIDAGVDELLNPQPSKDPPSPSCNVELFERLVAREKKNKLQPPTRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVVFAYISCAAAILPFWETELGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPW

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in brain cortex; cerebellum; dorsal root ganglion; spinal cord and testis. High expression in trigeminal ganglion; also expressed in autonomic nervous system ganglia such as the stellate ganglion and paravertebral sympathetic ganglia. Expressed in all adult spinal cord and brain regions; with slightly higher expression in thalamus; hypothalamus; hippocampus and posterior corte (at protein level). Expressed in all adult spinal cord and brain regions; with slightly higher expression in thalamus; hypothalamus; hippocampus and posterior corte (at protein level). Expressed in all adult spinal cord and brain regions; with slightly higher expression in thalamus; hypothalamus; hippocampus and posterior corte (at protein level). In non-neuronal tissues; substantial expression found in lung and heart and weal expression in liver; testis; kidney; small intestine and spleen

DOI ID

10.1074/jbc.m312229200; 10.1213/01.ane.0000168447.87557.5a; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1074/jbc.m602495200; 10.1113/jphysiol.2007.145649; 10.1074/jbc.m800712200; 10.1038/nn.2143; 10.1016/j.bbrc.2009.12.056; 10.1038/nm.2216

RefSeq

NP_997144.1